Holger Lösch studied political science, history and German studies and literature at the Ludwig Maximilian University in Munich. During his studies, he began working as a journalist and editor in the television department of Bayerischer Rundfunk. From 1995, he was Head of the Television Directorate of Bayerischer Rundfunk until he took over as Head of Central Program Coordination in 1998. In 2001, Holger Lösch moved from Bayerischer Rundfunk to the Schörghuber Corporate Group in Munich, where he worked as Head of Central Communications and Marketing until 2007. From 2006, he was also a member of the company management. From 2007 to 2008, he was responsible for Corporate Development, Communications and Customer Relation Management at Arabella Hotel-Holding, Munich. 

In 2008, he became Head of Communications and Marketing at BDI, and from 2009 he was also a member of the Executive Board. Holger Lösch has been a member of the Executive Board since July 2011 and Deputy Managing Director of the BDI since April 2017.

Holger Lösch has been involved in bilateral Germany-Australia energy cooperation over the last years, leading the feasibility study HySupply that looked at establishing an import partnership for renewable hydrogen products between Germany and Australia.